There are 1,000 maximum points one can receive:
- Homework assignments: 15% (150 points) The points are calculated as the number of correct answers for all assignments divided by the total number of questions for all assignments, times 150.
- Small group evaluation: 20% (200 points) Students who pass will receive 200 points, 180 points or 160 points. Students who fail will receive 120 points. Small group instructors will use their best judgement when assigning small group grades. Your instructor will evaluate you on such issues as your preparedness for class, your understanding of the course materials and your comments in small group.
- Paper critique: 20% (200 points) Students who pass may receive 200 points, 180 points, 160 points or 150 points on the paper. Students who fail will receive 120 points. Small group instructors will use their best judgement when assigning paper critique grades. This evaluation will include whether or not you appropriately address key issues in the paper, whether you correctly use epidemiology and biostatistics terms, the level of your insights into the paper, how well the paper is written and how it compares overall to papers written by other students in your small group. Students must Email any questions they have concerning their paper critique grade to their small group instuctors no later than mid-semester.
The final grades for the course will be Honors, Pass or Fail
There are two exams, the first representing 20% of your grade and the second 25% of your grade. The second exam will include concepts tested on the first exam. Before each exam, the course director will ask the class if they would like a formal review session. If the answer is yes - and it always has been - a time and location will be selected. Review sessions generally run about 90 minutes to two hours.
- Exam one: 20% (200 points) The points are calculated as the number of correct answers divided by the total number of questions, times 200.
- Exam two: 25% (250 points) The points are calculated as the number of correct answers divided by the total number of questions, times 250.
Please note that the exams represent only 45% of your evaluation. It is certainly possible for students to score above 90% on each exam and to obtain a grade of pass, not honors, for the course.
The two course textbooks were selected based on three criteria: (1) do they address most of the concepts the faculty wants you to know (2) will they serve as good resources for you as interns and residents participating in journal clubs; and (3) will they be adequate resources for you as attending physicians.
Epidemiology by Leon Gordis is the epidemiology text while the biostatistics text is Principles of Biostatistics by Marcello Pagano and Kimberlee Gauvreau. The texts are on reserve in the library. The texts contain some concepts that you'll not be expected to learn for this course. Like your own studies, the faculty must prioritize based on course goals and time.
Reading List for Small Groups
Following is a list of articles for the Epidemiology-Biostatistics reading list.
- Effects of Lifestyle Activity vs Structured Aerobic Exercise In Obese Women; JAMA, January 27, 1999, Vol 281, No 4, pages 335 - 340
- Effect of Risedronate On the Risk Of Hip Fracture In Elderly Women; NEJM, February 1, 2001, Vol 344, No 5, pages 333 - 340
- A Case-Control Study of Baldness In Relation To Myocardial Infarction In Men; JAMA, February 24, 1993, Vol 269, No 8, pages 998 - 1003
- Clinical And Genetic Features Of Ehlers-Danlos Syndrome Type IV, The Vascular Type; NEJM, March 9, 2000, Vol 342, No 10, pages 673 - 680
- A Comparison Of Enoxaparin With Placebo For The Prevention of Venous Thromboembolism In Acutely Ill Medical Patients; NEJM, September 9, 1999, Vol 341, No 11, pages 793 - 799
- A Prospective Study Of Walking As Compared With Vigorous Exercise In The Prevention Of Coronary Heart Disease In Women; NEJM, August 26, 1999, Vol 341, No 9, pages 650 - 658
- Phenylpropanolamine And The Risk Of Hemorrhagic Stroke; NEJM, December 21, 2000, Vol 343, No 25, pages 1826 - 1832
- Direct-to-Consumer Marketing of High-Technology Screening Tests; NEJM, 2-14-02, Vol 346, No 7, pages 529-532
- Intake of Fish and Omega-3 Fatty Acids and Risk of Stroke in Women; JAMA, 1-17-01, Vol 285, No 3, pages 304-312
- Evaluation of Acupuncture for Pain Control After Oral Surgery; Arch Otolaryngol Head Neck Surg; 5-99, Vol 125, pages 567-572
- Cognitive and Motor Outcomes of Cocaine-Exposed Infants; JAMA, 4-17-02, Vol 287, No 15, pages 1952-1960
- A Comparison of Enoxaparin With Placebo for the Prevention of Venous Thromboembolism in Acutely ill Medical Patients; NEJM, 9-9-99, Vol 341, Number 11, pages 793-799
- A Prospective Study of Walking as Compared With Vigorous Exercies in the Prevention of Coronary Heart Disease in Women; NEJM, 8-26-99, Vol 341, No 7, pages 529-532
- Screening For Lung Cancer; NEJM, November 30, 2000, Vol 343, No 22, pages 1627 - 1633
- Reporting Number Needed to Treat and Absolute Risk Reduction in Randomized Controlled Trials; JAMA, 6-5-02, Vol 287, No. 21, pages 2813-2814
- Extrapolation of Correlation Between 2 Variables in 4 General Medical Journal ; JAMA, 6-5-02, Vol 287, No. 21, pages 2815-2816
- How Statistical Expertise Is Used in Medical Research; JAMA, 6-5-02, Vol 287, No. 21, pages 2817-2820
- Publication Bias in Editorial Decision Making; JAMA, 6-5-02, Vol 287, No. 21, pages 2825-2828
- Postpublication Criticism and the Shaping of Clinical Knowledge; JAMA, 6-5-02, Vol 287, No 21, pages 2843-2847
- Media Coverage of Scientific Meetings: Too Much, Too Soon?; JAMA, 6-5-02, Vol 287, No 21, pages 2859-2863
- Analysis of Cases of Harm Associated With Use of Health Information on the Internet; JAMA, 6-5-02, Vol 287, No 21, pages 2869-2871
- Quality of Systematic Reviews of Economic Evaluations in Health Care; JAMA, 6-5-02, Vol 287, No 21, pages 2809-2812
- Users Guide to the Medical Literature 1. How to Get Started; JAMA, 11-3-93, Vol 270, No 17, pages 2093-2095
- Users Guide to the Medical Literature, How to Use an Article About Therapy or Prevention, Are the Results of the Study Valid ; JAMA, 12-1-93, Vol 270, N0 21, pages 2598-2601
- Users Guide to the Medical Literature, How to Use an Article About a Diagnostic Test, Are the Results of the Study Valid?; JAMA, 2-2-94, Vol 271, No 5, pages 389-391
- Users Guide to the Medical Literature, How to Use an Article About Therapy or Prevention, What Were the Results and Will They Help Me in Caring for My Patients?; JAMA, 1-5-94, Vol 271, No 1, pages 59-63
- Users Guide to the Medical Literature, How to Use an Article About a Diagnostic Test, What Are the Results and Will They Help Me in Caring for My Patients; JAMA, 3-2-94, Vol 271, No 9, pages 703-707
- Ten Rules for Reading Clinical Research Reports; American Journal of Surgery, June, 1990, Vol 159, pages 533-539
- Multivariate Analysis: A Primer for Readers of Medical Research ; Annals of Internal Medicine, 4-15-03, Vol 138, Number 8, pages 644-650
- Clinical Trials and Rare Disease; NEJM, Vol 348, No 24, pages 2455-2456
- The Continuing Unethical Conduct of Underpowered Clinical Trials ; JAMA, 7-17-02, Vol 288, No 3, pages 358-362
- Composite Outcomes in Randomized Trials: Greater Precision But With Greater Uncertainty; JAMA, 5-21-03, Vol 289, No 19, pages 2554-2559
- Clinical Trials, Multiple Treatments, Multiple End Points, and Multiple Lessons; JAMA, 5-21-03, Vol 289, No 19, pages 2575-2577
- Television Watching and Other Sedentary Behaviors in Relation to Risk of Obesity and Type 2 Diabetes Mellitus in Women; JAMA, 4-09-03, Vol 289. No 14, pages 1785-1791
- Academic Freedom in Clinical Research; NEJM, 10-14-02, Vol 347, No 17, pages 1368-1370
- Scope and Impact of Financial Conflicts of Interest in Biomedical Research, A Systemic Review; JAMA, 1-22/29-03, Vol 289, No 4, pages 454-465
- The Integral Role of Clinical Research in Clinical Care; NEJM, 4-03-03, Vol 348, No 114, pages 1368-1388
- The Therapeutic Orientation to Clinical Trials; NEJM, 4-03-03, Vol 348, No 114, pages 1383-1386
- Enrolling the uninsured in clinical trials: An ethical perspective; Crit Care Med, 2003, Vol 31, No 3 (Suppl.), pages S121-S125
- Ethical framework for the use of sham procedures in clinical trials; Crit Care Med, 2003, Vol 31, No 3 (Suppl.), pages S126-S129
- Research in children; Crit Care Med, 2003, Vol 31, No 3 (Suppl.), pages S131-S141
- Is the concept of informed consent applicable to clinical research involving critically ill patient?; Crit Care Med, 2003, Vol 31, N0 3 (Suppl.), pages S153-S159
- Ethical considerations for research in critically ill patients; Crit Care Med, 2003, Vol 31, No 3 (Suppl.), pages S178-S181
- Research ethics and the intensive care unit: Getting behind the wheel; Crit Care Med, 2003, Vol 31, No 3, pages S119-S120
- Statistical guidelines for the British Medical Journal; Br. J. Surgery, July 1991, Vol 78, pages 782-783
- Cost-Effectiveness and Cost-Benefit Analysis in the Medical Literature, Are the Methods Being Used Correctly?; Annals of Internal Medicine, 2-1-92, Vol 116, No 3, pages 238-244
- Factors Associated With Failure to Publish Large Randomized Trials Presented at an Oncology Meeting; JAMA, July 23/30, 2003, Vol 290, No 4, pages 495-501
- Registering Clinical Trials; JAMA, July 23/30, 2003, Vol 290, No 4, pages 516-523
- Coffee Consumption and Risk of Type 2 Diabetes Mellitus Among Middle-aged Finnish Men and Women; JAMA, March 10, 2004, Vol 291, No 10, pages 1213-1219
- Better Reporting of Harms in Randomized Trials: An Extension of the CONSORT Statement; Annals of Internal Medicine, November 16, 2004, Vol 141, Number 10, pages 781-788
- Clinical Research and the Physician-Patient Relationship, Annals of Internal Medicine, April 15, 2003, Volume 138, Number 8, pages 669-672
- Duplicate Publication, Multiple Problems, JAMA, October 13, 2004, Vol 292, No 14, pages 1745-1746
- Public Registration of Clinical Trials, NEJM, July 22, 2004, Vol 35, No 4, pages 315-317
- Trial Registration: A Great Idea Switches From Ignored to Irresistible, JAMA, September 15, 2004, Vol 292, No 11, pages 1359-1362
- The Discrepancy between Observat ional Studies and Randomized Trials of Menopausal Hormone Therapy: Did Expectations Shape Experience?, Annals of Internal Medicine, December 2, 2003, Volume 139, Number 11, pages 923-929
- Effectiveness of Acupuncture as Adjunctive Therapy in Osteoarthritis of the Knee, a Randomized, Controlled Trial, Annals of Internal Medicine, December 21, 2004, Vol 141, No 12, 901-910
- Improving Informed Consent and Enhancing Recruitment for Research by Understanding Economic Behavior, JAMA, Feb. 2, 2005, Vol 293, No 5, pages 609-612
- Research Compensation and the Monetarization of Medicine, JAMA, Feb 2, 2005, Vol 293, N0 5, pages 613-614