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» OCW Home » Basic Human Pathology: Parts I and II » Lectures 
Cellular Adaptations to Disease/Cell Injury and Death I
Authors: Michael Kahn, D.D.S., Lynn W. Solomon, D.D.S.
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Basic Human Pathology Lecture #1 Cellular Adaptations to Disease / Cell Injury & Death I Basic Human Pathology Lecture #1 Cellular Adaptations to Disease / Cell Injury & Death I
Definitions Definitions
Definitions (cont’d) Definitions (cont’d)
Review: Tissue, Cellular, and Plasma Membrane Anatomy and Terms Review: Tissue, Cellular, and Plasma Membrane Anatomy and Terms
Definitions Definitions
Parenchyma and Stroma Parenchyma and Stroma
Plasma Membrane Plasma Membrane
Reaction of Cells to Stimuli Reaction of Cells to Stimuli
Hypertrophy - Masseter Muscle Hypertrophy - Masseter Muscle
Hypertrophy Hypertrophy
Hypertrophy – Skeletal Muscle Hypertrophy – Skeletal Muscle
Left Ventricular Wall Hypertrophy of Cardiac Muscle – Left Ventricular Wall Hypertrophy of Cardiac Muscle –
Hypertrophy – Cardiac Muscle Hypertrophy – Cardiac Muscle
Nodular Hyperplasia – Prostate Nodular Hyperplasia – Prostate
Nodular Hyperplasia – Prostate Nodular Hyperplasia – Prostate
Hypertrophy and Hyperplasia Hypertrophy and Hyperplasia
Hypertrophy and Hyperplasia During Pregnancy Hypertrophy and Hyperplasia During Pregnancy
Physiological Hyperplasia – Physiological Hyperplasia –
Physiological Hyperplasia – Endometrium of Uterus Physiological Hyperplasia – Endometrium of Uterus
Developmental causes of reduced cell mass Developmental causes of reduced cell mass
Adaptation to Environmental Stress (cont’d) – <br> Adaptation to Environmental Stress (cont’d) –
Adaptation to Environmental Stress (cont’d) – Adaptation to Environmental Stress (cont’d) –
Adaptation to Environmental Stress (cont’d) Adaptation to Environmental Stress (cont’d)
Autophagy and Cell Atrophy Autophagy and Cell Atrophy
Adaptation to Environmental Stress (cont’d) Adaptation to Environmental Stress (cont’d)
Adaptation to Environmental Stress Adaptation to Environmental Stress
Local Atrophy - Disuse Local Atrophy - Disuse
Atrophy - Endocrine Atrophy - Endocrine
Atrophy Atrophy
Hemifacial Atrophy Hemifacial Atrophy
Adaptation to Environmental Stress (cont’d) Adaptation to Environmental Stress (cont’d)
Involution – Thymus Gland Involution – Thymus Gland
Adaptation to Environmental Stress (cont’d) Adaptation to Environmental Stress (cont’d)
Adaptation to Environmental Stress (cont’d) Adaptation to Environmental Stress (cont’d)
Cellular Adaptations to Disease/Cell Injury and Death I: Slide 35 Cellular Adaptations to Disease/Cell Injury and Death I: Slide 35
Respiratory Epithelium Prior to Metaplasia Respiratory Epithelium Prior to Metaplasia
Cellular Adaptations to Disease/Cell Injury and Death I: Slide 37 Cellular Adaptations to Disease/Cell Injury and Death I: Slide 37
Esophageal Mucosa Metaplastic to Stratified Squamous Epithelium Esophageal Mucosa Metaplastic to Stratified Squamous Epithelium
Ductal – Squamous Metaplasia Ductal – Squamous Metaplasia
Squamous Metaplasia Squamous Metaplasia
Summary of Adaptation to Environmental Stress Summary of Adaptation to Environmental Stress
Summary Summary
Cell Adaptation Key Facts Cell Adaptation Key Facts
Reaction of Cells to Injury Reaction of Cells to Injury
Reaction of Cells to Injury on a Biochemical Level Reaction of Cells to Injury on a Biochemical Level
Reaction of Cells to Injury on a Biochemical Level Reaction of Cells to Injury on a Biochemical Level
Function of Ubiquitin in Cell Stress Function of Ubiquitin in Cell Stress
Protein Kinesis Protein Kinesis
Reaction of Cells to Injury on a Biochemical Level Reaction of Cells to Injury on a Biochemical Level
Reaction of Cells to Injury on a Biochemical Level Reaction of Cells to Injury on a Biochemical Level
Free Calcium’s Role as a Destructive Agent Free Calcium’s Role as a Destructive Agent
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Hydropic Change Hydropic Change
Hydropic Change - Leukoedema Hydropic Change - Leukoedema
Hydropic Degeneration - Leukoedema Hydropic Degeneration - Leukoedema
Reversible Change – Cell Degeneration Reversible Change – Cell Degeneration
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Fatty Change Fatty Change
Fatty Change Fatty Change
Fatty Change - Liver Fatty Change - Liver
Fatty Change - Liver Fatty Change - Liver
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Hyaline Change – Liver Cell Hyaline Change – Liver Cell
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Labial Melanotic Macule – Focal Melanosis Labial Melanotic Macule – Focal Melanosis
Melanin Pigmentation – Labial Melanotic Macule Melanin Pigmentation – Labial Melanotic Macule
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Hemosiderin in Liver Cells Hemosiderin in Liver Cells
Hemosiderin – Lung Alveoli Hemosiderin – Lung Alveoli
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Hemochromatosis - Pancreas Hemochromatosis - Pancreas
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Lipofuscin – Striated Muscle and Liver Lipofuscin – Striated Muscle and Liver
Reversible Cellular Changes and Accumulations Reversible Cellular Changes and Accumulations
Pathologic Calcifications Pathologic Calcifications
Metastatic Calcification Hypercalcemia - Lung Metastatic Calcification Hypercalcemia - Lung
Pathologic Calcifications Pathologic Calcifications
Calcific Stenosis of Aortic Valve Calcific Stenosis of Aortic Valve
Dystrophic Calcification – Medial Sclerosis Dystrophic Calcification – Medial Sclerosis
Dystrophic Calcification – Medial Sclerosis Dystrophic Calcification – Medial Sclerosis
Dystrophic Calcification – Stomach Injury Dystrophic Calcification – Stomach Injury
Dystrophic Calcification – Periapical and Pulpal Pathoses Dystrophic Calcification – Periapical and Pulpal Pathoses
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