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Author: Michael Kahn, D.D.S.
Basic Human Pathology Lecture #2 Cellular Adaptations to Disease / Cell Injury & Death II Basic Human Pathology Lecture #2 Cellular Adaptations to Disease / Cell Injury & Death II
Reaction of Cells to Injury Reaction of Cells to Injury
Causes of Cell Injury (Injurious Stimuli) Causes of Cell Injury (Injurious Stimuli)
Causes of Cell Injury (Injurious Stimuli) - cont’d Causes of Cell Injury (Injurious Stimuli) - cont’d
Targets of Injurious Stimuli Targets of Injurious Stimuli
Targets of Injurious Stimuli - cont’d Targets of Injurious Stimuli - cont’d
Changes of Injury Changes of Injury
Changes of Injury - cont’d Changes of Injury - cont’d
Congestion Congestion
Edema – Alveoli and Bronchus Edema – Alveoli and Bronchus
Thrombus / Embolus - Kidney Thrombus / Embolus - Kidney
Thrombus Thrombus
Embolus at Celiac Trunk of Aorta Embolus at Celiac Trunk of Aorta
Changes of Injury Changes of Injury
Fibrosis - Keloid Fibrosis - Keloid
Fibrosis - Scar Fibrosis - Scar
Substance Accumulation Mechanisms Substance Accumulation Mechanisms
Gaucher’s Disease - Spleen Gaucher’s Disease - Spleen
Amyloidosis Amyloidosis
Amyloidosis Amyloidosis
Amyloidosis Amyloidosis
Asbestosis – Ferruginous Bodies Asbestosis – Ferruginous Bodies
Hypoxic Cell Injury Hypoxic Cell Injury
Hypoxic Cell Injury Hypoxic Cell Injury
Hypoxic Cell Injury Hypoxic Cell Injury
Hypoxic Cell Injury Hypoxic Cell Injury
Hypoxic Cell Injury Hypoxic Cell Injury
Hypoxic Cell Injury Hypoxic Cell Injury
Hypoxic Cell Injury Hypoxic Cell Injury
Localized Infarct – Necrotizing Sialometaplasia Localized Infarct – Necrotizing Sialometaplasia
Cellular response to ischemia Cellular response to ischemia
Free Radical Injury Free Radical Injury
Free Radical Injury Free Radical Injury
Free Radical Injury Free Radical Injury
Reactive oxygen metabolites damage cells Reactive oxygen metabolites damage cells
Cellular Adaptations to Disease/Cell Injury and Death II: Slide 36 Cellular Adaptations to Disease/Cell Injury and Death II: Slide 36
Chemical Cell Injury	Chemical Cell Injury
Apoptosis Apoptosis
Apoptosis Apoptosis
Apoptosis Apoptosis
Apoptosis Apoptosis
Apoptosis Apoptosis
Signaling and Execution Phases /        Degradation and Phagocytic Phases Signaling and Execution Phases / Degradation and Phagocytic Phases
Apoptosis Apoptosis
Apoptosis Apoptosis
Apoptosis Apoptosis
Mitochondrial Damage Mitochondrial Damage
Mitochondrial integrity –key factor in apoptosis Mitochondrial integrity –key factor in apoptosis
Summary Overview of Apoptotic Process Summary Overview of Apoptotic Process
Overview - Apoptosis Overview - Apoptosis
Necrosis Necrosis
Relationships between sub-lethal and lethal cell damage Relationships between sub-lethal and lethal cell damage
Necrosis Necrosis
Necrosis Necrosis
Necrosis Necrosis
Necrosis - Testis Necrosis - Testis
Necrosis Necrosis
Necrosis Necrosis
Necrosis Necrosis
Cell Injury - Nuclear Changes Cell Injury - Nuclear Changes
Cell Injury - Nuclear Changes Cell Injury - Nuclear Changes
Cellular Adaptations to Disease/Cell Injury and Death II: Slide 62 Cellular Adaptations to Disease/Cell Injury and Death II: Slide 62
Coagulative Necrosis - Cell Changes Coagulative Necrosis - Cell Changes
 Cardiac Muscle Cardiac Muscle
Coagulative Necrosis – Acute Myocardial Infarction Coagulative Necrosis – Acute Myocardial Infarction
Coagulative Necrosis – Acute Myocardial Infarction Coagulative Necrosis – Acute Myocardial Infarction
Coagulative Necrosis – Acute Myocardial Infarction Coagulative Necrosis – Acute Myocardial Infarction
Cellular Adaptations to Disease/Cell Injury and Death II: Slide 68 Cellular Adaptations to Disease/Cell Injury and Death II: Slide 68
Coagulative Necrosis – Kidney Coagulative Necrosis – Kidney
Coagulative Necrosis – Kidney Coagulative Necrosis – Kidney
Coagulative Necrosis - Kidney Coagulative Necrosis - Kidney
Coagulative Necrosis - Adrenal Gland Coagulative Necrosis - Adrenal Gland
Coagulative Necrosis - Chemical Burn Coagulative Necrosis - Chemical Burn
Necrosis Necrosis
Liquifactive Necrosis - Kidney Liquifactive Necrosis - Kidney
Liquifactive Necrosis - Lung Abscess Liquifactive Necrosis - Lung Abscess
Liquifactive Necrosis - Brain Liquifactive Necrosis - Brain
Liquifactive Necrosis – <br>Periapical Abscess Liquifactive Necrosis –
Periapical Abscess
Liquifactive Necrosis – Periodontal Abscess Liquifactive Necrosis – Periodontal Abscess
Liquifactive Necrosis – Abscess Liquifactive Necrosis – Abscess
Necrosis Necrosis
Caseous Necrosis - Kidney Caseous Necrosis - Kidney
Caseous Necrosis Caseous Necrosis
Caseous Necrosis Caseous Necrosis
Caseous Necrosis - Lung Caseous Necrosis - Lung
Caseous Necrosis - Tuberculosis Caseous Necrosis - Tuberculosis
Necrosis Necrosis
‘Wet’ Gangrenous Necrosis - Diabetic ‘Wet’ Gangrenous Necrosis - Diabetic
“Dry” Gangrene - Foot “Dry” Gangrene - Foot
Gangrenous Necrosis - NOMA Gangrenous Necrosis - NOMA
Necrosis Necrosis
Fibrinoid Necrosis - Artery Fibrinoid Necrosis - Artery
Necrosis Necrosis
Gummatous Necrosis – Tertiary Syphilis Gummatous Necrosis – Tertiary Syphilis
Gummatous Necrosis – Liver Gummatous Necrosis – Liver
Necrosis Necrosis
Fat Necrosis - Pancreas Fat Necrosis - Pancreas
Aging Aging
Cellular Aging Cellular Aging
Theories of Aging Theories of Aging