Tufts OpenCourseware
Author: Richard Glickman-Simon, M.D.

Session 4b: Aging and Longevity – Essentials

1. Learning Objectives

By the end of this session, you will be able to:

  • Describe the biology of aging at the molecular, cellular, systemic, and evolutionary levels

  • Distinguish between primary and secondary aging and explain the relevance of each to clinical geriatrics

  • Identify selected biomarkers for longevity and describe how they may be used to manipulate life expectancy or lifespan

  • Differentiate between clinical preventive services as applied to older adults and their younger counterparts

  • Speculate on what accounts for the extreme longevity of the oldest old

2. Readings

  • Westendorp RG. What is healthy aging in the 21st century? American Journal of Clinical Nutrition. 83(2):404S-409S, 2006 Feb.

  • Perls T. Terry D. Understanding the determinants of exceptional longevity. Annals of Internal Medicine. 139(5 Pt 2):445-9, 2003 Sep 2.

3. Additional Resources

  • Armbrecht, HJ. The biology of aging. Journal of Laboratory & Clinical Medicine. 138(4):220-225, October 2001

  • The Biology of Aging. Merck Manual of Geriatrics