Evidence-based Pain Therapy
	Overview
	Overview, cont.
	Study designs
	Gum and cavities
	RCT
	Cohort
	Cohort Studies: Prospective vs. Retrospective
	Case control
	Death rates per 1000 person - years
	Mean age - years
	Confounder
	RCT
	Adjusted death rates
	Case series
	Case series - problems
	Evidence-based Pain Therapy: Slide 17
	Narrative review
	Systematic reviews
	Differences between narrative and systematic reviews
	Systematic reviews
	Meta-analysis
	Overview
	Overview, cont.
	Presentation of results
	Treatment effect size and interpretation
	Treatment effect size and interpretation
	NNT
	Treatment effect size continuous data
	Forest plot
	Forest plot - Heterogeneity
	Overview
	Overview, cont.
	Statistically significant vs clinically significant
	How precise was the estimate of the treatment effect?
	Evidence of no effect vs lack of evidence
	Overview
	Overview, cont.

• First Animated Model: Yellow Submarine (1.854 Mb)-unit1
• Pharmacotherapy
• Swarm of Bees Tutorial-unit12
• Shark Animation tutorial-unit11
• Rabbit Medicine