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» OCW Home » Introduction to Clinical Pain Problems » Lectures 
Evidence-based Pain Therapy
Author: Soledad Cepeda, M.D.,Ph.D.
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Evidence-based Pain Therapy Evidence-based Pain Therapy
Overview Overview
Overview, cont. Overview, cont.
Study designs Study designs
Gum and cavities Gum and cavities
RCT RCT
Cohort Cohort
Cohort Studies: Prospective vs. Retrospective Cohort Studies: Prospective vs. Retrospective
Case control Case control
Death rates per 1000 person - years Death rates per 1000 person - years
Mean age - years Mean age - years
Confounder Confounder
RCT RCT
Adjusted death rates Adjusted death rates
Case series Case series
Case series - problems Case series - problems
Evidence-based Pain Therapy: Slide 17 Evidence-based Pain Therapy: Slide 17
Narrative review Narrative review
Systematic reviews Systematic reviews
Differences between narrative and systematic reviews Differences between narrative and systematic reviews
Systematic reviews Systematic reviews
Meta-analysis Meta-analysis
Overview Overview
Overview, cont. Overview, cont.
Presentation of results Presentation of results
Treatment effect size and interpretation Treatment effect size and interpretation
Treatment effect size and interpretation Treatment effect size and interpretation
NNT NNT
Treatment effect size continuous data Treatment effect size continuous data
Forest plot Forest plot
Forest plot - Heterogeneity Forest plot - Heterogeneity
Overview Overview
Overview, cont. Overview, cont.
Statistically significant vs clinically significant Statistically significant vs clinically significant
How precise was the estimate of the treatment effect? How precise was the estimate of the treatment effect?
Evidence of no effect vs lack of evidence Evidence of no effect vs lack of evidence
Overview Overview
Overview, cont. Overview, cont.
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