CKD Progression
	Progression of Chronic Kidney Disease
	Progression of Chronic Kidney Disease
	Pathologic Features
	Risk Factors Related to CKD
	Definition of Chronic Kidney Disease
	Outcomes of CKD
	Stages and Prevalence of CKD
	Serum Creatinine vs. GFR
	Pathophysiology of Stages of CKD
	Pathophysiology of Stages of CKD
	Puzzles in Pathophysiology of Chronic Kidney Disease
	Two patients
	Why does GFR Decline in Progressive Kidney Disease?
	Experimental Models of Chronic Kidney Disease
	Hemodynamic Findings in Experimental Kidney Disease
	Hypotheses
	Mechanisms of Progression
	Strategies to Interrupt Glomerular Adaptations
	Systemic and Glomerular Capillary Pressures in the Ablation Model
	ACE inhibition in ablation
	Chronic Kidney Disease - Progression: Slide 21
	Non-Diabetic Kidney Disease
	Summary of ACE Inhibitors Trials
	Summary of Therapies
	Conclusions (1)
	Conclusions (2)
	Two patients
	Conclusions (3)

• Chronic Kidney Disease - Progression
• Lecture 3: Descriptive Epidemiology
• LU1:Yellow Submarine-PDF tutorial
• Gout and Other Crystal Diseases
• Gout and Other Crystal Diseases
• LU3: Hand-PDF tutorial