Metabolic Acidosis
	Objectives
	Determinants of Arterial Blood Acidity
	Normal Arterial and Venous Values
	Definition
	Definition
	Sequential Response to an Acid Load
	Basic Mechanisms
	Basic Mechanisms
	Increased Acid Production
	Increased Acid Production
	Basic Mechanisms
	Decreased Acid Excretion
	Decreased Acid Excretion: Chronic Kidney Disease
	Relationship Between Serum Bicarbonate and Serum Creatinine
	Relationship Between Unmeasured Anions and Serum Creatinine
	Effect of an Acid Load
	Decreased Acid Excretion
	Basic Mechanisms
	Loss of Bicarbonate (HCO3-)
	Loss of Bicarbonate (HCO3-)
	Clinical Manifestations of Metabolic Acidosis
	Electrolyte/Metabolic Disturbances
	Metabolic Acidosis: Slide 24
	Increased Anion Gap - Metabolic Acidosis
	Normal Anion Gap - Metabolic Acidosis
	Serum Anion Gap - Chronic Kidney Disease
	Common Causes of - Metabolic Acidosis
	Major Causes of Metabolic Acidosis
	Two Examples
	Lactic Acidosis
	Diabetic Ketoacidosis - Pathogenesis
	Diabetic Ketoacidosis - Consequences
	Typical Deficits
	Diabetic Ketoacidosis - Treatment
	Metabolic Acidosis: Slide 36

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