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» OCW Home » Genetics » Lectures 
Cancer Genetics
Author: Jodi Dana Hoffman
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Cancer Genetics Cancer Genetics
Cancer Cancer
Some (Not All) Cancers Are Hereditary Some (Not All) Cancers Are Hereditary
Knudson’s 2-Hit Hypothesis Knudson’s 2-Hit Hypothesis
Two-hit theory of carcinogenesis (Knudson hypothesis) Two-hit theory of carcinogenesis (Knudson hypothesis)
Genes in Tumorigenesis Genes in Tumorigenesis
Genes in Tumorigenesis Genes in Tumorigenesis
The Medical Genetics Perspective The Medical Genetics Perspective
Factors To Look For in Hereditary Cancers Factors To Look For in Hereditary Cancers
Breast Cancer Breast Cancer
Why Test for BRCA1 and 2 Mutations? Why Test for BRCA1 and 2 Mutations?
BRCA1-2 Mutations Increase the Risk of Cancer More Than Other Factors BRCA1-2 Mutations Increase the Risk of Cancer More Than Other Factors
BRCA 1 and 2 are Tumor Suppressor Genes BRCA 1 and 2 are Tumor Suppressor Genes
Cancer Genetics Clinic Cancer Genetics Clinic
Indications for DNA Testing-I Indications for DNA Testing-I
Indications for DNA Testing-2 Indications for DNA Testing-2
Other Hereditary Syndromes Associated With Breast Cancer Other Hereditary Syndromes Associated With Breast Cancer
Penetrance Penetrance
Why Single Out Ashkenazi Jewish Women? Why Single Out Ashkenazi Jewish Women?
Costs of DNA Testing Costs of DNA Testing
Cancer Genetics: Slide 21 Cancer Genetics: Slide 21
Cancer Genetics: Slide 22 Cancer Genetics: Slide 22
How Genetic Testing Changes Management in the Woman With Breast Cancer How Genetic Testing Changes Management in the Woman With Breast Cancer
How Genetic Testing Changes Management for the Healthy Woman With A Positive Family History How Genetic Testing Changes Management for the Healthy Woman With A Positive Family History
Potential Disadvantages of Genetic Testing in the Woman With Breast or Ovarian Cancer Potential Disadvantages of Genetic Testing in the Woman With Breast or Ovarian Cancer
Potential Disadvantages of Genetic Testing in a Healthy Person Potential Disadvantages of Genetic Testing in a Healthy Person
Prevention Strategies for Known BRCA 1/2 Mutation Carriers Prevention Strategies for Known BRCA 1/2 Mutation Carriers
Prevention Strategies-2 Prevention Strategies-2
Prevention Strategies-3 Prevention Strategies-3
Limitations of DNA Testing Limitations of DNA Testing
Cancer Genetics: Slide 31 Cancer Genetics: Slide 31
MA Genetic Privacy Act MA Genetic Privacy Act
Colon Cancer Colon Cancer
Familial Adenomatous Polyposis Familial Adenomatous Polyposis
Clinical Characteristics of Classic FAP Clinical Characteristics of Classic FAP
Cancer Genetics: Slide 36 Cancer Genetics: Slide 36
HNPCC= Lynch syndrome HNPCC= Lynch syndrome
Take Home Message Take Home Message
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