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Author: Jennifer Coburn, Ph.D.
Damage to Host Damage to Host
Mechanisms of Damage Mechanisms of Damage
Mechanisms of Damage (cont.) Mechanisms of Damage (cont.)
Non-Toxin-Mediated Damage Non-Toxin-Mediated Damage
Non-Toxin-Mediated Damage (cont.) Non-Toxin-Mediated Damage (cont.)
Mechanisms of Damage (cont.) Mechanisms of Damage (cont.)
Non-Toxin-Mediated Damage (cont.) Non-Toxin-Mediated Damage (cont.)
Non-Toxin-Mediated Damage (cont.) Non-Toxin-Mediated Damage (cont.)
Non-Toxin-Mediated Damage (cont.) Non-Toxin-Mediated Damage (cont.)
Granuloma Formation Granuloma Formation
Immune Complex Deposition Immune Complex Deposition
Infection-Triggered Autoimmunity Infection-Triggered Autoimmunity
Mechanisms of Damage (cont.) Mechanisms of Damage (cont.)
Toxin Definitions Toxin Definitions
Toxin-Mediated Damage Toxin-Mediated Damage
Toxin Examples Toxin Examples
Active at Cell Surface Active at Cell Surface
Pore Formers Pore Formers
Phospholipases Phospholipases
Classical Superantigens Classical Superantigens
Active in Cytoplasm (A-B Toxins) Active in Cytoplasm (A-B Toxins)
Toxims that ADP-ribosylate Intracellular Substrates Toxims that ADP-ribosylate Intracellular Substrates
GTPase Cycle GTPase Cycle
Classical Mechanism of Intoxication Classical Mechanism of Intoxication
A-B Toxin Entry A-B Toxin Entry
Type II Secretion System-dependent Intoxication Type II Secretion System-dependent Intoxication
Cholera (1) Cholera (1)
Cholera Toxin (1) Cholera Toxin (1)
Cholera Toxin + NAD Cholera Toxin + NAD
Cholera Toxin (2) Cholera Toxin (2)
Cholera Toxin (3) Cholera Toxin (3)
Cholera Toxin (4) Cholera Toxin (4)
Cholera Toxin (5) Cholera Toxin (5)
Cholera (2) Cholera (2)
Anthrax: Basics Anthrax: Basics
Epidemiology of Anthrax in the 21st Century Epidemiology of Anthrax in the 21st Century
Anthrax: Cutaneous Anthrax: Cutaneous
Anthrax: Inhalational (1) Anthrax: Inhalational (1)
Anthrax: Inhalational (2) Anthrax: Inhalational (2)
Anthrax Toxin Subunits Anthrax Toxin Subunits
Recommended Postexposure Prophylaxis Recommended Postexposure Prophylaxis
Tetanus and Botulinum Neurotoxins Tetanus and Botulinum Neurotoxins
Botulinum and Tetanus Neurotoxins Botulinum and Tetanus Neurotoxins
Tetanus and Botulinum Neurotoxins (cont.) Tetanus and Botulinum Neurotoxins (cont.)
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