Damage to Host
	Mechanisms of Damage
	Mechanisms of Damage (cont.)
	Non-Toxin-Mediated Damage
	Non-Toxin-Mediated Damage (cont.)
	Mechanisms of Damage (cont.)
	Non-Toxin-Mediated Damage (cont.)
	Non-Toxin-Mediated Damage (cont.)
	Non-Toxin-Mediated Damage (cont.)
	Granuloma Formation
	Immune Complex Deposition
	Infection-Triggered Autoimmunity
	Mechanisms of Damage (cont.)
	Toxin Definitions
	Toxin-Mediated Damage
	Toxin Examples
	Active at Cell Surface
	Pore Formers
	Phospholipases
	Classical Superantigens
	Active in Cytoplasm (A-B Toxins)
	Toxims that ADP-ribosylate Intracellular Substrates
	GTPase Cycle
	Classical Mechanism of Intoxication
	A-B Toxin Entry
	Type II Secretion System-dependent Intoxication
	Cholera (1)
	Cholera Toxin (1)
	Cholera Toxin + NAD
	Cholera Toxin (2)
	Cholera Toxin (3)
	Cholera Toxin (4)
	Cholera Toxin (5)
	Cholera (2)
	Anthrax: Basics
	Epidemiology of Anthrax in the 21st Century
	Anthrax: Cutaneous
	Anthrax: Inhalational (1)
	Anthrax: Inhalational (2)
	Anthrax Toxin Subunits
	Recommended Postexposure Prophylaxis
	Tetanus and Botulinum Neurotoxins
	Botulinum and Tetanus Neurotoxins
	Tetanus and Botulinum Neurotoxins (cont.)

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