Systemic Lupus Erythematosus (SLE)
	Epidemiology of SLE
	Pathogenesis of SLE
	Pathogenesis of SLE
	Pathogenesis – Immunologic Abnormalities
	B cells in SLE
	T cells in SLE
	Pathogenesis – Immunologic factors
	Observed immune abnormalities in SLE
	Principle of IndirectImmunofluorescence
	Clinically relevant autoantibodies in SLE
	Mechanism of tissue damage in SLE
	Clinical Features of SLE
	Systemic Lupus Erythematosus (SLE): Slide 15
	Cutaneous Manifestations
	Cutaneous manifestations
	Cutaneous manifestations
	Pulmonary manifestations
	Cardiac manifestations
	Hematologic manifestations
	Gastrointestinal manifestations
	Neuropsychiatric (?25-50%) – Functional vs organic difficult
	Neuropsychiatric
	Lupus nephritis (50%)
	Lupus Nephritis – clinical presentation
	Classification of SLE with Reference to Glumerulonephritis
	Treatment of Lupus Nephritis – NIH Data
	1982 revised criteria for classification of systemic lupus erythematosus
	Management of SLE
	Gout and Other Crystal Diseases
	Future Therapies

• LU1:Yellow Submarine-PDF tutorial
• Systemic Lupus Erythematosus (SLE)
• Gout and Other Crystal Diseases
• Gout and Other Crystal Diseases
• Systemic Lupus Erythematosus (SLE): Slide 15
• Lecture 3: Descriptive Epidemiology